Jun 25th, 2020

Your hormone cycle will paint a picture of how you will age. It will also predict how healthy you will be for the rest of your life.

Your hormonal rhythm, which creates changes in your breasts, ovaries, brain, bones and heart, are important for your future health and a significant issue when it comes to aging.

Proper hormone replacement may save you from Cancer, Heart Disease, and Alzheimer’s ever becoming a reality for your future self.

Did you know that there are several hundred bodily processes not involved in reproduction, and more than a few thousand gene products, that require estrogen, as well as being involved in how well we age? Reproductive or not, our bodies always need estrogen.

If you are past the reproductive age, then replacing hormones in a way that mimics nature is the key. High levels of estrogen tell your brain that the uterus lining can stop growing (the nest is ready). Growth abruptly stops, literally, everywhere inside of you...all the way down to your mitochondria.

This peak of estrogen then creates progesterone receptors for the next two weeks of the progesterone phase of the cycle. The estrogen peak also floods your system with luteinizing hormone which then causes the corpus luteum (which means “yellow body”) to leak progesterone for about two weeks.

If no pregnancy occurs in a normal cycle, progesterone destroys every cell in every part of your body that is not supposed to be there to clean the slate for another try next month. This is a good thing!

So you see, progesterone steps in to sculpt and define the body and our health. Simultaneously it undoes all that estrogen has done to you everywhere else in your brain and body through apoptosis and estrogen receptor blocking.

So, as you can see, together, the regular, monthly dance of estrogen and progesterone play an important role in all aspects of your health.

Gretchen Jones PA-C is a recognized expert in the use of bioidentical hormones for treatment of ovarian dysfunction, menopause, peri-menopause and low testosterone in women and men. She is a leading advocate for changing the way in which hormone therapy is understood and managed by healthcare professionals. She provides the expertise, the experience, and the motivation necessary for successful bioidentical hormone replacement therapy. She can be reached at


  1. Role of folliculo-luteal function in human reproduction by György Siklósi
  2. Role of nox4 in mitochondrial oxidative stress and dysfunction : protection by estrogen by James Nicholas Horne
  3. The Role of Estrogen and Estrogen Analogues in Friedreich’s Ataxia Cytoprotection by Timothy E Richardson; James W Simpkins; University of North Texas. Health Science Center at Fort Worth
  4. Regulation of mitochondrial biogenesis by transcriptional coactivators and estrogen-related receptor A (Alpha) by Anastasia Kralli
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The goal of WHN is to expand the Standard of Care by promoting, advocating, and advancing women's wellbeing and longevity through clinical research and education about the benefits of Physiologic Restoration to reduce the symptoms of hormone imbalance, chronic disease and degenerative decline.
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